Located in the heart of Phoenix, Ariz., St. Joseph's Hospital and Medical Center is a 586-bed, not-for-profit hospital that provides a wide range of health, social and support services with special advocacy for the poor and underserved. St. Joseph's is a nationally recognized center for quality tertiary care, medical education and research. It includes the internationally renowned Barrow Neurological Institute, the Muhammad Ali Parkinson Center, the Norton Thoracic Institute, a campus of Creighton University's Medical School and the first Level I Trauma Center in Arizona verified by the American College of Surgeons. U.S. News & World Report routinely ranks St. Joseph's among the best hospitals in the United States for neurology and neurosurgery. For more information please visit our website at https://www.dignityhealth.org/arizona/locations/stjosephs.
Postdoctoral Position in Parkinson’s Disease Symptomology
Required Education/Experience/Skills: Doctoral degree in natural sciences and at least four years of experience working in a basic science laboratory. Skills required includes a strong working knowledge of neurobiology and associated techniques. A strong background in molecular biology including cloning, gene expression/PCR, AAV production and design, experience with creating, and handling, viral vectors, data generation and handling, data interpretation, writing up laboratory procedures and results, supervision of students, software usage. Experience with small pre-clinical model handling, surgeries, primary neuronal cell culture, immunohistochemistry, neurophysiology, and microscopy are a plus. Good command of written and spoken English is required.
Desired Education/Experience/Skills: Advanced molecular biology techniques such as cloning, recombinant protein production, and protein analysis. Electrophysiology and/or calcium imaging. Knowledge of brain anatomy, enteric nervous system function, tissue sectioning, immunohistochemistry and microscopy, specifically in fluorescence immunolabeling; preclinical model handling, survival surgery, behavioral testing- working knowledge of levodopa-induced dyskinesia is a plus.
Job Summary: This postdoctoral fellow position will coordinate several projects aimed at investigating the cause of non-motor symptoms in Parkinson’s disease. This includes studies evaluating the gut-brain axis in neurodegenerative disease, the role of alpha-synuclein in symptomology, and the role of non-dopamine circuits. As part of the project, a strong emphasis will be placed on the design and evaluation of novel viral vectors. These vectors will be utilized to study disease proteins and circuits in various preclinical models of disease. The fellow will participate in the day to day operations of the research lab; duties will include collaborative experimental design, conducting experimental laboratory work, analyzing and writing up results for publication in peer-reviewed journals. In addition, some supervisory responsibilities will be provided, as well as opportunities to learn about current laboratory operations, including preclinical model survival surgery, behavioral testing, experimental subject euthanasia, post-mortem analyses of tissue sample preparation; tissue sectioning, immunohistochemistry, etc.
Doctoral degree, Ph.D., D.Sc., M.D. Ph.D., D.Sc., or M.D. Ability to conceive new/innovative ideas or solutions with good logic and problem solving skills; ability to communicate, write, advise and counsel on extremely complex and technical matters; knowledge of operating required lab equipment and minor surgical procedures as required. ability to conceive new/innovative ideas or solutions with good logic and problem solving skills; ability to communicate, write, advise and counsel on extremely complex and technical matters; knowledge of operating required lab equipment and minor surgical procedures as required.
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